Center for Process Analytical Chemistry (CPAC)

Final Program

CPAC SATELLITE WORKSHOP
UW ROME CENTER 

March 20-22, 2006
Co-hosted with Volker Hessel, IMM, Germany and Eindhoven University of Technology, Netherlands 
and Paul Watts, U Hull, UK

Micro-Reactors and Micro-Analytical

Monday, March 20  - CPAC Satellite Meeting, University of Washington (UW) Rome Center, Rome, Italy

12:30  Meeting Registration Opens - UW Rome Center
13:00 Welcome and Introduction: Mel Koch, CPAC, and Daniel T. Schwartz, Associate Dean, College of Engineering, UW, USA
13:15 Plenary Presentation: Process Intensification and Exploring Novel Processing Routes by Microstructured Reactors
Volker Hessel, Institut for Mikrotechnik Mainz GmbH (IMM), Germany and Eindhoven University of Technology, Netherlands
13:55 High Throughput Synthesis of Analytically Pure Compounds within Flow Reactors 
Paul Watts, Chemistry, U of Hull, UK
14:20 Instrumentations for Monitoring Microreaction Processes
Stefan Loebbecke, Fraunhofer ICT, Pfinztal, Germany
14:45 Participant Introductions
15:00 Break
15:30 Dynamic Surface Tension Measurements
Emilia Bramanti, Italian National Research Council (CNR), Institute for Chemical and Physical Processes (IPCF), Pisa, Italy
16:00 The Integration of Spectral and Process Data in Process Performance Monitoring
Julian Morris, CPACT and Chemical Engineering and Advanced Materials, U of Newcastle, UK 
16:30 Grating Light Reflection Spectroscopy (GLRS) - Diffraction Gratings as a Chemical Sensing Platform
Gordon Mitchell, CPAC Graduate Student, Lloyd Burgess Group, UW, USA
16:45 Long Path Capillary Optical Waveguide - From Waveguides to Cell Isolation Systems
Joseph Dragavon, CPAC Graduate Student, Lloyd Burgess Group, UW, USA
17:00 Review of Today's Topics and Preparing for Tuesday's Program
Ray Chrisman, CPAC Visiting Scholar, UW, USA
18:00-20:00 CPAC Reception 'con Apertivo', Director's Apartment, UW Rome Center, co-hosted with Corporate & Foundation Relations, UW, USA

Tuesday, March 21 - CPAC Satellite Meeting, UW Rome Center, Italy

9:00 Liquid Phase Process Characterization using Micro-Reactors
Ray Chrisman, CPAC Visiting Scholar, UW
9:25 On-Line Process Monitoring by Miniaturized Liquid Chromatography
Scott Gilbert, Crystal Vision-Microsystems SA and CPAC Visiting Scholar
9:50 On-Line Process and Emission Monitoring by Robust Spectroscopy-Based Instrumentation
Alain Ferber, Sintef, Norway 
10:15 Break
10:45

Developments in Micro-NMR
Michael J. McCarthy, U of California, Davis, USA

11:10 Advanced Water Analysis: On-Chip Separation and Detection of Proteins
Wayne Einfeld, Sandia National Laboratories
11:35 Examples of Advances in Measurement Science that are Enhanced by CPAC's New Sampling/Sensor Initiative (NeSSI™)
Brian Marquardt, CPAC, UW
12:05 Lunch in Ristorante da Pancrazio located in the Palazzo Pio
14:00 Microreactors without Walls
Barry Lutz, Post Doc, Engineering, and Dan Schwartz, Acting Associate Dean, Engineering, UW
14:25 New Standardized Microfluidic Devices for Aggressive Chemistry in Microreaction Systems
Thomas R. Dietrich, mikroglas chemtech GmbH and MicroChemTec
14:55 Process Optimization using PAT
Gerhard Korb, Sanofi-Aventis
15:25 Break
15:55 Case Study: Micro-Reactors from Laboratories to Production
Hanns Wurziger, Merck KGaA, Germany
16:25 High Throughput Cell Culture Experimentation with BioProcessors SimCell™ Platform
Ache Stokelman, Amgen
16:55 Flip Chart Oriented Discussion Session: Mel Koch, Volker Hessel, Paul Watts, and Ray Chrisman
17:30-19:30 CPAC Reception 'con Apertivo', Director's Apartment, UW Rome Center, co-hosted with Corporate Relations and Development, UW, USA

Wednesday, March 22 - CPAC Satellite Meeting, UW Rome Center, Italy 

09:00 Selected CPAC Technical Talks
9:00 Micro-Sequential Injection: Applications to Biochemical Assays and Process Monitoring
Jaromir Ruzicka, Professor, Department of Chemistry, University of Washington, USA
9:10 Micro Biosensors Based on Surface Plasmon Resonance
Clement Furlong, Medical Genetics, UW, USA
9:20 Analytical Control of a Micro-Reactor
Stu Farquharson, Real-Time Analyzers, and Brian Marquardt, CPAC, UW
9:30 Better Processes for Better Compounds at Minimal Cost - the Economics and Science of Switching from Batch to Continuous
Thomas Schwalbe, Micro-Reactor Systems Provider, Inc. (MRSP), USA
10:00 Autonomous Microsensors for Chemical Analysis: Problems and Perspectives
Alanson Sample, Kishore Sundara-Rajan, and Abhinav Mathur, Graduate Students, and Alex Mamishev, Professor, Electrical Engineering, UW
10:20-12:00 Summarize Flip Chart Conclusions, Discussion Sections, and Develop Action Items
Ray Chrisman, Volker Hessel, Mel Koch, Paul Watts
12:00 Meeting concludes