Fact Sheet

Summer 2008

Center for Process Analytical Chemistry
University of Washington, Box 351700
Seattle, WA  98195-1700,
(206) 685-2326, FAX: (206) 543-6506
Web site:  http//www.cpac.washington.edu

CPAC BACKGROUND

The Center for Process Analytical Chemistry (CPAC) is a self-sustaining organization, with a successful consortium of sponsors recruited from all sectors of industry.

The present CPAC program can be summarized by two main components:

· new measurement approaches including the miniaturization of traditional instrumentation and the development of new sensors and non-traditional instruments,

· mechanisms for interaction, collaboration, and communication of Center activities, research programs, and information related to process analytical technology (PAT) among sponsors, other universities and academic departments, government agencies, and the general measurement and control community.  CPAC has an established track record in fostering academic/industrial/national laboratory interactions, which aim at bridging the gap between basic research and full-scale process/product development.

Within CPAC, the following sponsor focus groups (both industry and technology-based) serve as a forum for discussion and guidance concerning the industrial relevance of research projects undertaken by the Center.

Industrial:

· Materials & Chemical Processes

· Oil & Petrochemicals
· Food & Consumer Products
· Pharmaceuticals & Biotechnology

 

Technical:

· Chemometrics
· Process Optimization/Control
· Spectroscopy/Imaging

· Chromatography
· Sensors 

CPAC INITIATIVES AND PLATFORM PROJECTS

· Fermentation Monitoring (FermI)

The optimization of bio-reactors is of importance due to the value of industrial bio-technology, as well as the increasing interest in bio-fuels and bio-sustainability.  CPAC is involved with several research projects to develop measurement tools that will compliment existing monitoring methods and allow for studies to optimize bio-reactions and related process control.

· Micro-Reactors and Instrumentation

Several CPAC Research Projects are emphasizing micro-analytical and micro-sensor development.

· New Sampling/Sensor Initiative (NeSSI)- see description below  

PERSONNEL

Faculty Director · Rob Synovec
Executive Director · Mel Koch
Adm. Manager · Nan Holmes
UW, Chemistry 
· Anatol Brodsky
·
Lloyd Burgess
· James Callis
 
· Scott Gilbert
· Bart Kahr
· Robert Synovec
· Dave Veltkamp
UW, Applied Physics Laboratory (APL) 
· Brian Marquardt  
UW, Elect. Engr. 
· Alex Mamishev
· Brian Otis
· Babak Parviz
· Tim Strovas
UW, Forest Resources 
· Richard Gustafson  · Renata Bura
· Ray Chrisman
UW, Medical Genetics 
· Clement Furlong  · Scott Soelberg  
U. of Delaware 
· Steven Brown 
U. of Maine 
· Scott Collins 
U. of Minnesota 
· Kent Mann 
U. of California -- Davis 
· Mike McCarthy
· Jeffrey de Ropp 
· Jeffrey Walton  

PERSONNEL DISTRIBUTION:

UW PI's
Grad Students
Staff

16
17
3

Off Site PIs
Post-Docs

6
2

INDUSTRIAL ADVISORY BOARD

CPAC presently has 16 Full Sponsor organizations, each having a seat on the Industrial Advisory Board (IAB) that helps guide CPAC research and operations. CPAC also has 15 Associate (Vendor/Instrumentation) Sponsors to aid in the technology transfer/commercialization of CPAC technology.
IAB Chair Carl Rechsteiner, Chevron
Past Chair Carol Zrybko, Kraft
Chair Elect Jeff Gunnell, ExxonMobil
 
 

RESEARCH PROJECTS

Chemometrics: 

· Novel Tools Combining Data Mining and Statistical Inferencing Techniques, Brown 

· New Approaches to Updating and Transfer of Multivariate Calibrations·, Brown 

 
Sensors: 

· Integrating Fermentation with Biosensor Analysis of Bioprocess Components, Furlong

· Grating Light Reflection Spectrometry, Burgess/Brodsky 

· Vapochromic Detection and  Identification of Important Analytes, Mann/Marquardt/Veltkamp 

· Ultra-Low Cost Micro-Scale Wireless Monitoring of Chemical Processes, Parviz/Otis

· Adaptive Optics to Visualize and Quantitate Dynamic Processes, Burgess 

 · Application of Novel Membranes for Separation and Concentration Lignocellosic Biorefineries, Gustafson/Marquardt/Bura/Chrisman

Spectroscopy: 

· Evaluating Raman Spectroscopy to Improve Process Monitoring and Materials Characterization, Marquardt /Veltkamp·

· Control of Manufacturing Parameters with Fringing Field Sensors, Mamishev 

· Development of a Micro NMR System, McCarthy/Walton/de Ropp/Collins 

 

Chromatography: 

· Water Liquid Chromatography  and Microfabricated Systems, Synovec 

· Process Gas Chromatography and Chemometrics, Synovec 

Process Optimization and Control: 

· Utilizing NeSSI for Analytical Applications, Veltkamp/Marquardt

 

·Fermentation Initiative (FermI), Furlong/Marquardt/Veltkamp

 

RECENT HIGHLIGHTS 

New Sampling/Sensor Initiative (NeSSI):  This is an ad-hoc group of end-users and equipment manufacturers who are looking to modularize and miniaturize process analyzer sample system components to simplify and standardize sample system design. The goals for NeSSI are to facilitate the acceptance and implementation of miniature, modular sample systems that has resulted in an  ISA SP76 standard and to promote the concept of "smart" analytical systems by closely integrating flow, pressure and temperature with analytical sensors.

Process Analytical Technology (PAT)  and Quality by Design (QbD): CPAC has been involved with the PAT and QbD programs at FDA, including participating in training programs for selected reviewers and inspectors.

Summer Institute Program: The CPAC Summer Institute is a multidisciplinary forum open to both sponsor and non-sponsor participants. The importance of interdisciplinary communication is key to discussion of topics addressing the development and potential of micro-instrumentation for impacting high throughput experimentation and process intensification. 

CPAC Satellite Workshop in Rome, Italy focuses on multi-disciplinary and multi-industry developments of Micro-reactors and Micro-Analytical which impact future high throughput research and novel approaches to production, particularly in the pharmaceutical and biotechnology industries.